Endocrine Abstracts

Twelve years following hemicolectomy for colon adenocarcinoma, a 75-year-old patient with prostate cancer was treated for 4 weeks with the antiandrogen nilutamide and then with the long-acting GnRH agonist buserelin. The serum testosterone and prostate-specific antigen (PSA) levels had decreased dramatically after 3 months of treatment. After 2 years of buserelin administration, the hormonal state was examined. Serum estradiol, testosterone, DHEA, DHEAS, FSH and LH levels prov...

In the reproductive age, it is well-known that males are more sensitive to cardiovascular ischemic disease than females. In our study, we investigated the role of heme-oxigenase synthase (HO), which produce endogenous vascular protective carbon monoxide, in the development of sexual dimorphism in rats. We found that HO synthase enzyme activity, and the expression its HO-1 and HO-2 isoenzyme were increased in female rat aorta and left heart ventricle compared to males. Moreover...